Subcutaneous zygomycosis, which is typically seen in children and adolescents, results from infection with a pathogenic fungus, Basidiobolus haptosporus. It first develops as a localized lesion, usually on the thighs or buttocks, and it spreads slowly to form a hard, painless, non-pitting mass involving the cutaneous and subcutaneous tissues. The mass is shiny and tense initially, but may later become ulcerated. Subcutaneous zygomycosis has been reported in southeastern Asia and Africa. In Africa, India, South America and the West Indies, lesions similar to those of subcutaneous zygomycosis, but occurring on the face, may be caused by the fungus Conidiobolus coronatus.
Remission sometimes occurs spontaneously. Most cases respond satisfactorily to potassium iodide (see Subcutaneous fungal infections - Sporotrichosis). Oral ketoconazole or itraconazole, 200-400 mg daily, may also be effective.