Accelerated Degradation Experiment
Conditions
Procedure A: |
30 days exposure at 50 °C and 100% relative humidity. |
Procedure B: |
30 days exposure at 50 °C and 100% relative humidity followed by 7 days at 70 °C and 100% relative humidity. |
Appearance of the substance
The material, originally in the form of a transparent, colourless liquid, remains unchanged after procedures A and B.
Gain of moisture
Before exposure to heat and humidity: |
39% |
After procedure A: |
60% |
After procedure B: |
86% |
Chromatographic test
Adsorbent: Silica gel G
Solution applied to the plate: Substance dissolved in ethane 95%.
Solvent system:
n-butanol ................. 6 volumes
acetic acid ............... 2 volumes
water ....................... 2 volumes
Development conditions: The solvent is allowed to migrate until the front reaches 15 cm from the starting line.
Detection: The plate is left in a chromatographic chamber containing some iodine crystals until spots appear.
Results: The spots obtained from the solutions of each of the samples subjected to procedures A and B and the spot obtained from the reference solution of sodium lactate display the same chromatographic characteristics of migration and detection.
pH value
Prepare a 2% solution of the substance in water.
Indicator |
Before exposure to heat and humidity |
After procedure A |
phenol red |
yellow |
red-orange |
bromothymol blue |
green |
blue |
Conclusion
Sodium lactate is subject to decomposition under accelerated degradation conditions.
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