Accelerated Degradation Experiment
Conditions
Procedure A: |
30 days exposure at 50 °C and 100% relative humidity. |
Procedure B: |
30 days exposure at 50 °C and 100% relative humidity followed by 5 days at 70 °C and 100% relative humidity. |
Appearance of the substance
The substance, originally in the form of a white, crystalline mass at temperatures below 25 °C and a colourless liquid at temperatures above 25 °C, acquires after procedure A a pale yellow colour and after procedure B an orange colour.
Gain of moisture
None after procedures A and B.
Chromatographic test
Adsorbent: Silica gel F-254
Solution applied to the plate: Substance dissolved in methanol.
Solvent system:
chloroform .................. 90 volumes
acetone ........................ 10 volumes
acetic acid .................... 5 volumes
Development conditions: The solvent is allowed to migrate until the front reaches a line 15 cm from the starting line.
Detection: The plate is left in chromatographic chamber containing some iodine crystals until spots appear.
Results: After procedure A, additional spots were revealed. The degradation was estimated at 2%. After procedure B, the degradation was estimated at about 5%.
Conclusion
Undecylenic acid is subject to decomposition under accelerated degradation conditions.
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