Guidelines on the Use of International Nonproprietary Names (INNs) for Pharmaceutical Substances
(1997; 41 pages) View the PDF document
Table of Contents
Open this folder and view contents1. General introduction
Close this folder2. Elements in the INN system
View the document2.1 Proposed INNs
View the document2.2 Recommended INNs
View the document2.3 Names for radicals and groups
View the document2.4 Modified INNs (INNMs)
View the document2.5 Cumulative list of INNs
Open this folder and view contents3. Principles for selection of INNs
View the document4. Protection of INNs
Open this folder and view contents5. How to apply for an INN
View the document6. References for supporting material
View the documentAnnex 1: Background information on the INN programme
View the documentAnnex 2: General principles for guidance in devising international nonproprietary names for pharmaceutical substances
View the documentAnnex 3: List of common stems used in the selection of INNs
View the documentAnnex 4: Specific groups of biological compounds
View the documentAnnex 5: WHA46.19 - Nonproprietary names for pharmaceutical substances
View the documentAnnex 6: Procedure for the selection of international nonproprietary names for pharmaceutical substances
View the documentAnnex 7: Applications for INNs through national authorities (addresses)
View the documentAnnex 8: INN request form
 

2.3 Names for radicals and groups

During the 1975 meeting on Nonproprietary Names for Pharmaceutical Substances the experts discussed the issue of INNs for salts and esters and noted that requests had frequently been received for INNs for salts, esters, or combination products of substances for which INNs already existed. At that time, the experts decided that INNs for the simple salt and esters should be devised from the INN in conformity with normal chemical practice.

Some of the radicals and groups involved are, however, of such complex composition that it makes it inconvenient to use the chemical nomenclature. It was thus decided that in such cases, shorter nonproprietary names are selected for these inactive moieties and published in proposed lists under the title “Names for Radicals and Groups”. Separate names for salts and esters derived from this procedure are not published. If a “radical and group name” is used in conjunction with an INN, they are referred to as International Nonproprietary Name (Modified) or INNM.

A comprehensive list of radicals and groups may be obtained from the Distribution and Sales unit or the INN Secretariat (INNs: Names for radicals and groups, combined summary list, WHO/PHARM S/NOM 1506, updated regularly).

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