Search


Current filters:

New search
Add filters

Refine your search


Results 1-10 of 382.
Item hits:
Ethylene oxide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
International Programme on Chemical Safety; United Nations Environment Programme; International Labour Organization; World Health Organization; WHO Task Force on Ethylene Oxide ( 1985 )
Abstract

Ethylene oxide is a colourless, highly reactive, and flammable gas widely used as an intermediate in the production of various chemicals. Human exposure occurs mainly through inhalation in sterilization facilities and in production plants. Exposure may also occur through fumigated foods, pharmaceutical products, and sterilized medical equipment. This report uses a comprehensive review of the scientific literature on ethylene oxide to evaluate the associated risks for human health and the environment.On the basis of extensive data derived from animal investigations, test systems, and epidemiological findings suggesting an increase in the incidence of human cancer, the report concludes that ethylene oxide should be considered as a probable human carcinogen, and that its levels in the environment should be kept as low as feasible

Thumbnail
Arsine : human health aspects
Czerczak, S; Fishbein, Lawrence; World Health Organization; International Programme on Chemical Safety ( 2002 )
Dimethylformamide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization ; first draft prepared by A. Bainova
World Health Organization; International Programme on Chemical Safety ( 1991 )
Abstract

Evaluates risks to human health and the environment posed by the production and use of dimethylformamide, an organic solvent produced in large quantities throughout the world. Dimethylformamide is widely used in the chemical industry as a solvent, an intermediate, and an additive, with the largest quantities used in the production of acrylic fibres and polyurethanes. Dimethylformamide is also used in the production of pharmaceutical products. The opening sections outline the main sources of human and environmental exposure and review studies of the behaviour of dimethylformamide in the environment. Because of its complete solubility in water, dimethylformamide is noted to move readily through soils; accumulation in the food chain is judged unlikely. Concerning effects on organisms in the environment, the limited data available suggest low toxicity for aquatic organisms. The second half of the book reviews findings useful in determining the risks to health posed by exposure of workers and of the general population to dimethylformamide. An extensive review of findings from experimental studies reveals consistent evidence that dimethyl-formamide is a hepatotoxic agent. Both teratogenic and embryotoxic effects have been demonstrated in several species. The final section, which evaluates data from human studies, notes that symptoms associated with cases of acute accidental occupational poisoning are transient and followed by complete recovery. Biochemical signs of liver dysfunction are observed to accompany long-term repeated occupational exposure, but evidence suggesting an increased risk of certain cancers in exposed workers was judged inadequate

Kelevan / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization
World Health Organization; International Labour Organization; United Nations Environment Programme; International Programme on Chemical Safety; WHO Task Group on Environmental Criteria for Organochlorine Pesticides ( 1986 )
Abstract

Assesses available data on the risks for human health and the environment posed by kelevan, a chlordecone derivative used in a number of countries as an insecticide, mainly for the control of the potato beetle and the banana root borer. The opening sections summarize what is known about the properties of kelevan, sources of exposure, environmental transport and distribution, levels in the environment, and kinetics and metabolism. A section devoted to the effects of kelevan on organisms in the environment concentrates on the findings from a very limited number of studies. In view of the sparsity of data on kelevan, the report bases its recommendations on what is known about the toxicity of chlordecone, concluding that, unless kelevan is indispensable, it should not be used

Thumbnail
Elemental mercury and inorganic mercury compounds : human health aspects
Fisher, John F; World Health Organization; International Programme on Chemical Safety ( 2003 )
Neurotoxicity risk assessment for human health : principles and approaches
Harry, G. J; Kulig, B; Lotti, M; Ray, D; Tilson, H; Winneke, G; World Health Organization; International Programme on Chemical Safety ( 2001 )
Toxicological evaluation of certain veterinary drug residues in food / prepared by the fifty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JEFCA)
Joint FAO/WHO Expert Committee on Food Additives. Meeting (54th : 2000: Geneva, Switzerland); World Health Organization; Food and Agriculture Organization of the United Nations; International Programme on Chemical Safety ( 2000 )
Biomarkers in risk assessment : validity and validation
World Health Organization; International Programme on Chemical Safety ( 2001 )
Safety evaluation of certain food additives and contaminants / prepared by the fifty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JEFCA)
Joint FAO/WHO Expert Committee on Food Additives. Meeting (55th : 2000: Geneva, Switzerland); World Health Organization; Food and Agriculture Organization of the United Nations; International Programme on Chemical Safety ( 2001 )
Thumbnail
Barium and barium compounds
Choudhury, Harlal; Cary, Richard; World Health Organization; International Programme on Chemical Safety ( 2001 )