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Ethylene oxide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
International Programme on Chemical Safety; United Nations Environment Programme; International Labour Organization; World Health Organization; WHO Task Force on Ethylene Oxide ( 1985 )
Abstract

Ethylene oxide is a colourless, highly reactive, and flammable gas widely used as an intermediate in the production of various chemicals. Human exposure occurs mainly through inhalation in sterilization facilities and in production plants. Exposure may also occur through fumigated foods, pharmaceutical products, and sterilized medical equipment. This report uses a comprehensive review of the scientific literature on ethylene oxide to evaluate the associated risks for human health and the environment.On the basis of extensive data derived from animal investigations, test systems, and epidemiological findings suggesting an increase in the incidence of human cancer, the report concludes that ethylene oxide should be considered as a probable human carcinogen, and that its levels in the environment should be kept as low as feasible

Kelevan / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization
World Health Organization; International Labour Organization; United Nations Environment Programme; International Programme on Chemical Safety; WHO Task Group on Environmental Criteria for Organochlorine Pesticides ( 1986 )
Abstract

Assesses available data on the risks for human health and the environment posed by kelevan, a chlordecone derivative used in a number of countries as an insecticide, mainly for the control of the potato beetle and the banana root borer. The opening sections summarize what is known about the properties of kelevan, sources of exposure, environmental transport and distribution, levels in the environment, and kinetics and metabolism. A section devoted to the effects of kelevan on organisms in the environment concentrates on the findings from a very limited number of studies. In view of the sparsity of data on kelevan, the report bases its recommendations on what is known about the toxicity of chlordecone, concluding that, unless kelevan is indispensable, it should not be used

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Inventory of IPCS and other WHO pesticide evaluations and summary of toxicological evaluations performed by the Joint Meeting on Pesticide Residues (JMPR) : evaluations through 2000
Joint FAO/WHO Meeting on Pesticide Residues; World Health Organization. Promotion of Chemical Safety Unit; Inter-Organization Programme for the Sound Management of Chemicals; United Nations Environment Programme; International Labour Organization; International Programme on Chemical Safety ( 2001 )
Ammonia / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
International Programme on Chemical Safety; United Nations Environment Programme; International Labour Organization; World Health Organization ( 1986 )
Abstract

An expert assessment of the effects on human health and the environment posed by ammonia. Prepared by a 14-member task group, the book bases its evaluations on more than 600 published reports of epidemiological, laboratory, and clinical investigations, including controlled studies in man. The most extensive sections of the book are devoted to the effects of ammonia in the aquatic and terrestrial environments where, as a result of urbanization, industry, and farming, significant toxic effects of ammonia may arise. Readers will find especially detailed assessments of the effects on aquatic animals as well as effects on cattle, swine, and poultry resulting from continuous exposure under confined housing conditions. Information on the kinetics and metabolism of ammonia and on its effects on experimental animals and in vitro systems is also presented

Principles for evaluating health risks from chemicals during infancy and early childhood : the need for a special approach / published under the joint sposorship of the United Nations Environment Programme, the International Labour Organisation, the World Health Organization, and on behalf of the Commission of the European Communities
International Programme on Chemical Safety; Commission of the European Communities; United Nations Environment Programme; International Labour Organization; World Health Organization ( 1986 )
Abstract

Elaborates basic principles for the evaluation of chemical toxicology that are specific to the physiological characteristics of infants and young children. Principles of evaluation, which were worked out by 46 leading experts, are based on a thorough review of data on postnatal physiology, metabolism, and the special factors governing exposure in this age group, including behavioural and cultural conditions. Following background information on relevant features of postnatal morphology, biochemistry, and physiology, chapters assess the kinetics of absorption, biotransformation, and elimination and point out ways in which certain conditions of postnatal development will influence the effects of chemicals on different organs and systems. The book concludes with a discussion of factors that can assist in the identification of children at risk

Guide to short-term tests for detecting mutagenic and carcinogenic chemicals / prepared for the IPCS by the International Commission for Protection Against Environmental Mutagens and Carcinogens
International Commission for Protection Against Environmental Mutagens and Carcinogens; International Programme on Chemical Safety; United Nations Environment Programme; International Labour Organization; World Health Organization ( 1985 )
Abstract

A fully referenced document offering guidance in the field of short-term testing for mutagens and genotoxic carcinogens. In view of the acknowledged limitations in the capacity of short-term tests t screen for mutagenicity and carcinogenicity, the report attempts to explain the types of test that are commonly employed and the meaning that the results of such tests may have in the assessment of possible human hazards. The most extensive section contains descriptions, in phylogenetic order, of the most commonly used and most widely accepted assays. Emphasis is placed on the specific minimum scientific and technical criteria regarded as critical factors in obtaining data of acceptable quality and reliability. The next section discusses additional criteria that relate to good laboratory practice in genetic toxicology and to the type and quality of laboratory facilities. The report concludes with guidelines for the selection, application, and interpretation of short-term tests

Propylene oxide / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organization and the World Health Organization
International Programme on Chemical Safety; United Nations Environment Programme; International Labour Organization; World Health Organization ( 1985 )
Abstract

Propylene oxide is a colourless, highly volatile, and flammable liquid primarily used as a chemical intermediate. Small amounts are used for the sterilization of medical equipment and for the fumigation of foodstuffs. The main route of human exposure is through inhalation at the work-place. This report evaluates available scientific data on the risks posed by propylene oxide to human health and the environment. On the basis of this analysis, the report concludes that propylene oxide should be regarded, for practical purposes, as presenting a carcinogenic risk for man, and that levels in the environment should be kept as low as feasible

Report of the Sixth Meeting of the IPCS/INTOX Poisons Centre Working Group and Training Course in the Use of the IPCS/INTOX Package in Information Management at Poisons Information Centres, 5-9 September 1993, Sainte-Foy, Quebec, Canada
IPCS/INTOX Poisons Centre Working Group. Meeting (6th: 1993 : Quebec, Canada); World Health Organization. Programme for the Promotion of Chemical Safety; International Programme on Chemical Safety; International Labour Organization; United Nations Environment Programme; Training Course in the Use of the IPCS/INTOX Package in Information Management at Poisons Information Centres (1993 : Quebec, Canada) ( 1993 )
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Basic analytical toxicology / R. J. Flanagan ... [et al.]
Flanagan, R. J; Braithwaite, R. A; Brown, S. S; Widdop, B; Wolff, F. A. de; World Health Organization; International Programme on Chemical Safety; International Labour Organization; United Nations Environment Programme ( 1995 )
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Hazardous chemicals in human and environmental health : a resource book for school, college and university students
International Programme on Chemical Safety; World Health Organization. Promotion of Chemical Safety Unit; United Nations Environment Programme; International Labour Organization; Inter-Organization Programme for the Sound Management of Chemicals ( 2000 )