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Methyl isobutyl ketone / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization ; first draft prepared by K. Chipman
Chipman, K; World Health Organization; International Programme on Chemical Safety ( 1990 )
Abstract

Evalutes risks to human health and the environment posed by the widespread production and use of methyl isobutyl ketone as a solvent, with major applications in the production of lacquers and paint solvents, including car and industrial spray paints. Methyl isobutyl ketone also occurs naturally in food, is a permitted flavouring agent, and is used in food contact packaging materials. Sections concerned with the behaviour of methyl isobutyl ketone in the environment note its rapid evaporation into the atmosphere, rapid photo-transformation, ready biodegredation, and low potential for bioaccumulation. A review of data on metabolic pathways and toxicity to organisms concludes that production and use of this chemical pose no threat to wildlife or the environment, except in the case of accidental spills or inappropriate disposal of wastes. A review of studies conducted in human volunteers and in occupationally-exposed workers concludes that exposure to methyl isobutyl ketone can cause eye and respiratory irritation as well as symptoms of headache, nausea, and vertigo. The review found no evidence that exposure to this chemical causes permanent damage to the nervous system of workers or that its presence in the environment and in food poses any threat to the general population

n-Hexane / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
International Programme on Chemical Safety; World Health Organization ( 1991 )
Abstract

Evaluates the risks to human health and the environment posed by n-hexane, a chemical isolated from natural gas and crude oil and used in food processing to extract vegetable oil from beans, nuts, and seeds. n-Hexane is also used as a solvent, a cleaning agent, in the rubber industry, and in the manufacture of pharmaceuticals. The opening sections review what is known about the behaviour of this highly volatile chemical in the environment and its metabolic fate in experimental animals and in the human body. A review of investigations in experimental animals and in vitro test systems concentrates on testicular lesions and neurotoxicity as the principal effects of repeated exposure to n-hexane. Studies have also shown that neurotoxicity induced by n-hexane is enhanced by co-exposure to methyl ethyl ketone, methyl isobutyl ketone, and lead acetate; co-exposure to toluene decreases the neurotoxic effects of n-hexane. These findings are further supported by observations in humans, which draw upon several reports of peripheral neuropathy in workers exposed to n-hexane and in abusers of glues or solvents containing this chemical. The report notes that the majority of occupational cases have occurred in poorly ventilated small industries. While concluding that n-hexane is not likely to present a hazard to either the general population or the environment, the report stresses the need for precautions in the occupational setting, including the use of suitably designed work processes and engineering controls for reducing atmospheric levels below the recommended occupational exposure limits. The book further recommends the use of protective clothing and the ready availability of respiratory protection for use in enclosed spaces and in emergencies

Quintozène / publié sous la triple égide du Programme des Nations Unies pour l' environnement, de l' Organisation internationale du travail et de l' Organisation mondiale de la santé
International Programme on Chemical Safety; Task Group Meeting on Environmental Health Criteria for Organochlorine Pesticides other than DDT (Endosulfan) Quintozene Tecnazene Tetradifon ( 1984 )
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Report and presentations of a Joint Symposium on the Indoor Environment & Respiratory Illness, including Allergy, Ustroñ, Poland, 25-27 September 1997
Joint Symposium on the Indoor Environment and Respiratory Illness, including Allergy (1997 : Ustroñ, Poland); International Programme on Chemical Safety; World Health Organization; Inter-Organization Programme for the Sound Management of Chemicals ( 1998 )
Phenol : health and safety guide
World Health Organization; International Programme on Chemical Safety ( 1994 )
Berilio : gu'ia para la salud y la seguridad
Pan American Health Organization; International Programme on Chemical Safety ( 1993 )