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Title: Assessing human health risks of chemicals : derivation of guidance values for health-based exposure limits / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
Authors: World Health Organization
International Programme on Chemical Safety
Issue Date: 1994
Publisher: Geneva : World Health Organization
Language: English
Japanese
Russian
Polish
Abstract: Outlines methods and procedures for the derivation of guidance values for protecting the health of humans exposed to chemical substances. Guidance values provide quantitative information from risk assessment for regulatory authorities and other risk managers, and provide a basis for the establishment of national or local exposure limits and standards. The approach described relates primarily to long-term exposure of the general opulation in the ambient environment. Addressed to all involved in chemical safety, the book aims to promote consistency in the methods used when evaluating the health effects of environmental chemicals and formulating credible conclusions. Information ranges from guidance on the use of uncertainty factors when human data are lacking, through advice on how to establish a tolerable intake when a chemical shows more than one adverse effect, to examples of cases where a guidance value should not be established. The first section introduces key terms and explains the two principal methodological concepts: development of a tolerable intake on the basis of interpretation of available toxicity data, and allocation of the proportions of the tolerable intake to various environmental media. The second section describes procedures for determining a tolerable intake on the basis of toxicity data. Section three sets out a series of steps to be followed when extrapolating from a toxicity data base to a tolerable intake, moving from selection of a pivotal study and critical effects, through interspecies extrapolation, to a final review of the total uncertainty factor. The concluding section offers advice on the allocation of tolerable intakes to derive guidance values
Description: Summary and evaluation; conclusions and recommendations also in French and English
DC.HQ
73 p.
Subject: Hazardous Substances
Environmental Exposure
Guidelines
Context: toxicity
metadata.dc.subject.other: Chemical Toxicology and Carcinogenicity
URI: http://www.who.int/iris/handle/10665/40675
Other Identifiers: 9241571705
5225032850 (Russian)
Appears in Collections:Publications



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