Malaria vaccine development : pre-erythrocytic stages , proceedings of a conference held in the National Naval Medical Center, Bethesda, Maryland, USA, 12-15 April 1989 / edited by S. L. Hoffman & L. J. Martinez ; sponsored by the Naval Medical Research Institute (NMRI)
AbstractRecords the proceedings of a conference convened to consider new strategies for the development of malaria vaccines targeted to induce immune responses at the pre-erythrocytic stages of infection. During the conference, investigators from throughout the world reported on characterization of the biology, immunology, molecular biology, and epidemiology of sporozoite and liver stages of the parasite, and progress towards the development of vaccines against these pre-erythrocytic stages. Papers are grouped under six main headings. The first features two reviews of the pioneering studies, conducted in human volunteers between 1971 and 1975, which initially demonstrated that attenuated sporozoites can induce protection against human malaria. Papers in the second group reflect the wide range of approaches being used to determine whether antibodies to the circumsporozoite (CS) protein can protect against sporozoite infection. T-cell immunity against the CS protein forms the focus for the third group of papers, which record progress in understanding how the parasite interacts with host cells and how host defence mechanisms function against the parasite in nonimmunized and immunized hosts. Other papers investigate the liver as a target for vaccine-induced immunity and report work on non-CS sporozoite and liver-stage antigens. The concluding section reviews the role of epidemiological studies in attempts to define the components of the immune response that are responsible for naturally acquired protective immunity
Hoffman, S. L, Martinez, L. J, Naval Medical Research Institute (U. S.) & World Health Organization. (1990). Malaria vaccine development : pre-erythrocytic stages , proceedings of a conference held in the National Naval Medical Center, Bethesda, Maryland, USA, 12-15 April 1989 / edited by S. L. Hoffman & L. J. Martinez ; sponsored by the Naval Medical Research Institute (NMRI). Geneva : World Health Organization. http://www.who.int/iris/handle/10665/40080
Bulletin of the World Health Organization ; v. 68. Supplement
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