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Title: Methylmercury / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
Authors: World Health Organization
International Programme on Chemical Safety
Issue Date: 1990
Publisher: Geneva : World Health Organization
Language: English
Russian
Japanese
Abstract: Evaluates the risks to adult and fetal health posed by exposure to compounds of monomethylmercury. In view of the irreversible neurological damage produced in sever cases of poisoning, the book makes a special effort to clarify the ways in which this highly mobile metal enters the food chain and to define the levels that constitute a risk to human health. Close to 400 recent investigations, including numerous clinical studies following outbreaks of poisoning, are critically assessed. The main part of the book evaluates the large number of experimental, epidemiological, and clinical studies relevant to the assessment of health effects in humans. A review of studies in animals and in in vitro test systems, conducted since 1976, documents the consistent neurotoxicity and fetotoxicity of methylmercury, providing further support to the mechanistic models used to evaluate data in humans. Chapters devoted to effects in humans draw upon what has been learned from poisoning outbreaks in Minamata, Japan and in Iraq as well as from studies of populations consuming high quantities of fish in Canada and New Zealand. An evaluation of effects on developing tissues draws upon the considerable amount of new data available on dose-response relationship, concluding that prenatal life is especially sensitive to the toxic effects of methylmercury. The final chapter issues conclusions concerning levels of exposure and the associated risks to health in the general public, in populations consuming high quantities of fish, and in pregnant women. While the general public is determined to be at low risk of methylmercury poisoning, populations consuming high quantities of fish may attain a blood methylmercury level associated with a low risk of neurological damage to adults. In view of the particular sensitivity of the fetus to methylmercury, exposure during pregnancy is judged to carry a high risk of neurological disorder in the offspring
Description: jap issued by: Kumamoto : National Institute for Minamata Disease
144 p.
Subject: Methylmercury Compounds
Mercury Poisoning
metadata.dc.subject.other: Chemical Toxicology and Carcinogenicity
URI: http://www.who.int/iris/handle/10665/38082
Other Identifiers: 9241571012
5225019269 (Russian)
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