Differentiating early adult dengue from acute viral respiratory infections – A comparative analysis.
AbstractThe clinical presentations of dengue disease in adults are not fully described. Differentiating dengue from other acute viral respiratory infections (ARIs) is important. We conducted a prospective study from January 2008 to March 2010, recruiting subjects with early febrile illness presenting within the first 72 hours of illness at primary care outpatient clinics. This study evaluates cases enrolled to identify distinguishing clinical features of early dengue infection from ARIs. Acute and convalescent venous blood and nasal swab specimens were collected. Dengue was confirmed by RT-PCR, virus isolation, IgM/IgG seroconversion or fourfold IgG titre increase in paired blood samples. Non-dengue cases were tested for respiratory viruses from nasal swabs by RT-PCR. Dengue was confirmed in 49 patients along with 151 cases of influenza, 10 of parainfluenza and 29 patients of other viruses. The demographics between dengue (n=49) and PCR-positive viral ARI cases (n=190) did not differ significantly except by age (mean 39.1 years vs 33.7 years respectively; P
Thein, Tun-Linn, Ooi, Eng-Eong, Low, Jenny GH & Leo, Yee-Sin. (2011). Differentiating early adult dengue from acute viral respiratory infections – A comparative analysis.. WHO Regional Office for South-East Asia.. http://www.who.int/iris/handle/10665/171010