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Title: Dengue fever in a tertiary hospital in Makkah, Saudi Arabia
Authors: Shahina, W
Nassara, A
Kalkattawia, M
Bokharia, H
Issue Date: Dec-2009
Publisher: WHO Regional Office for South-East Asia.
Place of publication: New Delhi
Language: English
Abstract: Dengue fever is endemic in the western part of Saudi Arabia. This study aimed at describing the clinical and laboratory profiles of dengue fever patients admitted to a tertiary hospital in Makkah, Saudi Arabia, from 2006 to 2008. A total of 159 dengue fever patients were admitted during the spring and early summer. Their mean age was 25.6±16.1 years. Males outnumbered females by a ratio of 2:1. Of them, 143 patients (89.9%) had classic dengue fever and 16 patients (10.1%) had dengue haemorrhagic fever (DHF); one of them developed severe dengue shock syndrome (DSS) and died (0.6%). The common symptoms were highgrade fever, headache and body aches (100%), nausea and vomiting (27%), retro-orbital pain (25%), skin rash (16.4%), dry cough (8.2%) and haemorrhagic manifestations (3.14%). The main laboratory abnormalities were leukopenia (WBCs less than 4000/cmm) in 53.7% of patients, thrombocytopenia (platelet count less than 100 000/cmm) in 36.2% of patients and prolonged partial thromboplastin time (PTT) (>1.5 times of control value) in 33% of patients. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated more than five-fold in 35.2% of patients. The mean AST/ALT were 226.7/164 U in DF while in DHF these were 555/314 U. Twenty-six patients (16.4%) developed skin rash and had a significantly lower ALT value and a higher platelet count than those without rash
Keywords: Dengue Hemmorragic Fever
Dengue Virus
Dengue virus
Dengue Haemorrhagic Fever
Saudi Arabia
Clinical Symptoms
AST/ALT ratio
ISSN: 0250-8362
Appears in Collections:Dengue Bulletin

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