Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever.
AbstractThe pathological mechanism of dengue haemorrhagic fever (DHF) is still poorly understood. Previous studies have suggested that immune responses contribute to an increase in capillary permeability. We examined the levels of cytokines and activated endothelial substances in serum samples collected from DHF patients in Indonesia. We measured the levels of soluble TNF-R1, MCP-1, GM-CSF, IL-17, TNF-α, soluble thrombomodulin, soluble E-selectin, soluble ICAM-1 and soluble VCAM-1. The levels of activated endothelial substances such as sE-selectin, sICAM-1 and sVCAM-1 were higher in DHF patients than in healthy controls. High levels of soluble activated endothelial substances suggest that endothelial cells are highly activated. When compared with patients with other febrile illness (OFI) or healthy controls, the levels of sTNF-R1 were higher in DHF patients. A similar trend was observed in the level of thrombomodulin. MCP-1, GM-CSF and IL-17 were not detected in serum samples from any patients and healthy controls. TNF-α was detected in 5(9%) of 53 patients. The results suggest that endothelial cells are highly activated in DHF patients and TNF-α is one of the factors which contributes to the activation.
Ernawati Dewi, Beti, Takasaki, Tomohiko, Sudiro, T. Mirawati, Nelwan, R.H. & Kurane, Ichiro. (2007). Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever.. WHO Regional Office for South-East Asia.. http://www.who.int/iris/handle/10665/170398
DescriptionDengue Bulletin. 2007 Dec; 31: 103-110.
MetadataShow full item record
Showing items related by title and MeSH subject.
Evaluation of serum levels and significance of soluble CD40 ligand in screening patients with hepatitis C virus-related hepatocellular carcinoma Eltaher, S. M.; El Gil, R.; Fouad, N.; Mitwali, R.; El Kholy, H. (2016)The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma [HCV-HCC] patients. Sera concentration of circulating sCD40L and IL-10 were assayed using ELISA in 30 HCV positive patients with HCC, 30 HCV-positive patients with liver cirrhosis and 30 age-matched healthy volunteers with negative anti-HCV-Ab as a control group. Serum sCD40Lshowed statistically-significant high levels in HCV-HCC patients compared to HCV-cirrhotic patients and normal controls [P < 0.001]. Serum sCD40L had higher ...
Recent developments in production and purification of malaria antigens: Soluble antigens released in vitro from erythrocytes infected with Plasmodium berghei* Weissberger, H.; Golenser, J.; Spira, D. T. (1979)
Comparative studies of Leishmania soluble antigens by crossed-immunoelectrophoresis: demonstration of specific antigens to L. mexicana and L. braziliensis* Leon, Leonor L.; van Hoegaerden, Michel; Galvão-Castro, Bernardo (1986)