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Title: Autoimmunity in dengue virus infection.
Authors: Lin, Chiou-Feng
Lei, Huan-Yao
Liu, Ching-Chuan
Liu, Hsiao-Sheng
Yeh, Trai-Ming
Chen, Shun-Hua
Lin, Yee-Shin
Issue Date: Dec-2004
Publisher: WHO Regional Office for South-East Asia
Place of publication: New Delhi
Language: English
Abstract: Dengue haemorrhagic fever (DHF) is a complicated disease associated with viral and immune pathogenesis. There is still no effective vaccine to prevent the progression of DHF because of its undefined pathogenic mechanisms. The generation of autoimmunity in dengue virus (DEN) infection has been implicated in dengue pathogenesis. Based on our previous studies showing antibodies (Abs) against DEN nonstructural protein 1 (NS1) cross-reacted with human platelets and endothelial cells, a mechanism of molecular mimicry may contribute to autoantibody (autoAb) production. Here, the generation of autoAbs against human endothelial cells in patients infected with different DEN serotypes is shown. The levels of autoAbs present in different disease stages of DHF and the induction of endothelial cell apoptosis by patient sera were also determined. The results suggest that autoimmune responses are implicated in dengue disease pathogenesis and cause concern in vaccine development.
Description: Dengue Bulletin. 2004 Dec; 28: 51-57.
Keywords: Dengue Hemorrhagic Fever
Dengue Virus
Autoimmunity
URI: http://www.who.int/iris/handle/10665/163993
ISSN: 0250-8362
Appears in Collections:Dengue Bulletin



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