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Enhancement of MHC class I binding and immunogenic properties of the CTL epitope peptides derived from dengue virus NS3 protein by anchor residue replacement
The immunogenecity of the defined H-2Kd-restricted, murine cytotoxic T lymphocyte (CTL) epitopesof dengue viruses were examined for CTL induction in epitope peptide / H-2Kd tetramer assays. Thepeptides used in the study included those corresponding to amino acid (a.a.) residues 298-306(GYISTRVEM) of NS3 of dengue virus types 2 and 4 (named DENV-2/4), and to a.a. residues 299-307(GYISTRVGM) of NS3 of dengue virus types 1 and 3 (named DENV-1/3), and their respective modified epitope peptides, DENV-2/4-9L (GYISTRVEL) and DENV-1/3-9L (GYISTRVGL), in ...
Elevated lavels of soluble tumour necrosis factor receptor 1, thrombomodulin and soluble endothelial cell adhesion molecules in patients with dengue haemorrhagic fever.
The pathological mechanism of dengue haemorrhagic fever (DHF) is still poorly understood. Previous studies have suggested that immune responses contribute to an increase in capillary permeability. We examined the levels of cytokines and activated endothelial substances in serum samples collected from DHF patients in Indonesia. We measured the levels of soluble TNF-R1, MCP-1, GM-CSF, IL-17, TNF-α, soluble thrombomodulin, soluble E-selectin, soluble ICAM-1 and soluble VCAM-1. The levels of activated endothelial substances such as sE-selectin, sICAM-1 ...