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Title: Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population
Authors: Karam, W.
Jurjus, R.
Khoury, N.
Khansa, H.
Assad, C.
Zalloua, P.
Jurjus, A.
Issue Date: 2004
Language: English
Abstract: A direct correlation between HIV infection and mutation in the chemokine receptor [CCR5] gene has been established. However, such correlation has never been investigated in Lebanon. We report the frequency of the CCR5-delta 32 mutation in a r and om sample of 209 healthy, HIV-1 seronegative Lebanese aged 19-68. Overall, 4.8% were heterozygous for the mutation. Homozygosity was absent from our sample. The frequency for the CCR5-delta 32 allele was 2.5%. Distribution of the mutation was unaffected by sex, age, religion or educational level. The frequency in the Lebanese population is consistent with that in the origin of the mutation in northern Europe. This could be attributed to a gene flow into the Middle East from northern Europe
Description: 671-675
Keywords: Aged
Analysis of Variance
Blood Donors
Frameshift Mutation
Gene Deletion
Gene Flow
Gene Frequency
Genetics, Population
Subject: Chemokine Receptor
ISSN: 1020-3397
Other Identifiers:
Appears in Collections:EMRO Journal Articles (EMHJ)

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