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Title: Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester
Authors: Adam, I.
Idris, H.M.
El Bashir, M.I.
Issue Date: 2004
Language: English
Abstract: A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester [mean gestational age 8.5 weeks] were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted [3.8%] and 2 patients [7.7%] experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancy
Description: 560-565
Keywords: Administration, Oral
Drug Resistance
Endemic Diseases
Gestational Age
Parasite Egg Count
Pregnancy Outcome
Subject: Antimalarials
ISSN: 1020-3397
Other Identifiers:
Appears in Collections:EMRO Journal Articles (EMHJ)

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