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Title: Low-dose quinine for treatment of chloroquine-resistant falciparum malaria in Sudanese pregnant women
Authors: Adam, I.
Ibrahim, M.H.
Aelbasit, I.A.
El Bashir, M.I.
Issue Date: 2004
Language: English
Abstract: Pregnant Sudanese women who presented at a hospital in eastern Sudan with chloroquine-resistant falciparum malaria were randomly allocated to one of two quinine regimens: low-dose [10 mg/kg 2 times/day] [18 patients] or st and ard [10 mg/kg 3 times/day] [24 patients]. Treatment was for 7 days and follow-up for 28 days. Significantly fewer patients in the low-dose group reported vomiting and abdominal pain than the st and ard regimen group. Hypoglycaemia, preterm labour and recrudescence were slightly but not significantly higher in patients in the st and ard group than low-dose group. There were no significant differences between the groups in the mean time from admission to remission of fever and parasite clearance. We tentatively advocate the use of quinine 2 times/day to reduce side-effects and improve compliance
Description: 554-559
Keywords: Administration, Oral
Chloroquine
Drug Administration Schedule
Drug Resistance
Fever
Gestational Age
Hypoglycemia
Malaria, Falciparum
Quinine
Subject: Antimalarials
URI: http://www.who.int/iris/handle/10665/119448
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/1004_5/10_4-5_2004_554_559.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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