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Title: Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey
Authors: Tamer, L.
Tanriverdi, K.
Ercan, B.
Unlu, A.
Sucu, N.
Pekdemir, H.
Atik, U.
Issue Date: 2004
Language: English
Abstract: Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding [Arg 3500 ----> [corrected] Gln, Arg 3500 ----> [corrected] Trp and Arg 3531 ----> [corrected] Cys]. We estimated the frequency of Apo B point mutations [codon 3500] C9774T [Arg 3500 ----> [corrected] Trp] and G9775A [Arg 3500 ----> [corrected] Gln] in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them
Description: 125-130
Keywords: Apolipoprotein B-100
Apolipoproteins A
Case-Control Studies
Cholesterol, HDL
Gene Frequency
Rare Diseases
Subject: Apolipoproteins B
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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