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Title: Filariasis elimination in Egypt: impact of low microfilaraemics as sources of infection for mosquitoes
Authors: Farid, H.A.
Kamal, S.A.
Weil, G.J.
Adham, F.K.
Ramzy, R.M.R.
Issue Date: 2003
Language: English
Abstract: The elimination strategy for lymphatic filariasis aims at reducing blood microfilaraemia to levels at which vector transmission cannot be sustained. We aimed to determine whether patients with pre-treatment low or ultra-low microfilaria [MF] counts could be a reservoir of infection after mass drug administration [MDA] with a combined regimen. Laboratory-reared mosquitoes were fed on 30 volunteers after 2 rounds of MDA. Microfilaria uptake, infectivity rates and number of Wuchereria bancrofti L3 per mosquito were assessed. One year after MDA-1, 6 subjects transmitted MF, but up to 9 months after MDA-2 transmission failed. Six months after MDA-2 > 90% had clear MF smears and either failed to transmit MF or transmitted MF that did not develop to L3. We conclude that the transmission cycle is seriously weakened after MDA-2
Description: 863-872
Keywords: Albendazole
Carrier State
Disease Reservoirs
Feeding Behavior
Insect Vectors
Parasite Egg Count
Time Factors
Wuchereria bancrofti
Subject: Filariasis
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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