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Title: Field evaluation of latex agglutination test for detecting urinary antigens in visceral leishmaniasis in Sudan
Authors: El Safi, S.H.
Abdel Haleem, A.
Hammad, A.
El Basha, I.
Omer, A.
Kareem, H.G.
Boelaert, M.
Chance, M.
Hommel, M.
Issue Date: 2003
Language: English
Abstract: A latex agglutination test to detect urinary antigens for visceral leishmaniasis [VL] was studied. In 204 patients with suspected VL, KAtex had a sensitivity of 95.2% with good agreement with microscopy smears but poor agreement with 4 different serology tests. It was also positive in 2 confirmed VL cases co-infected with HIV. In all KAtex-positive confirmed cases actively followed up after treatment, the test became negative 1 month after completion of treatment. While KAtex had a specificity of 100% in healthy endemic and non-endemic controls, the direct agglutination test [DAT] was positive in 14% of the KAtex-negative healthy endemic controls. KAtex is a simple addition to the diagnostics of VL particularly at field level and as a complementary test for the diagnosis of VL in smear-negative cases with positive DAT results
Description: 844-855
Keywords: Antigens, Protozoan
Case-Control Studies
Child, Preschool
Endemic Diseases
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
Latex Fixation Tests
Leishmania donovani
Subject: Leishmaniasis, Visceral
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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