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Title: Prevalence of endocrine complications in beta-thalassaemia major in the Islamic Republic of Iran
Authors: Shahriari, M.
Sadjadian, N.
Issue Date: 2003
Language: English
Abstract: To identify the prevalence of endocrine dysfunction in Iranians with beta-thalassaemia, we assessed thyroid, parathyroid, pancreatic and adrenal function in 150 beta-thalassaemic patients aged 10-22 years at the Paediatrics Unit, Shiraz University of Medical Sciences. Primary hypothyroidism was found in 6.0% of patients [mean age: 14.6 +/- 1.9 years], hypoparathyroidism in 7.3% [14.5 +/- 3.2 years], type 1 diabetes mellitus in 7.3% [13.9 +/- 2.8 years] and adrenal insufficiency in 1 patient. The relatively high frequency of endocrine dysfunction found in our study may be a result of poor disease control and management in early life when irreversible tissue damage occurs due to iron overload. These findings reinforce the importance of regular follow-up of patients with beta-thalassaemia major for early detection and management of associated complications
Description: 55-60
Keywords: Adrenal Insufficiency
Blood Transfusion
Growth Disorders
Iron Chelating Agents
Subject: beta-Thalassemia
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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