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Title: Antioxidant micronutrients in children with thalassaemia in Egypt
Authors: Nasr, M.R.
Ali, S.
Shaker, M.
El Gabry, E.
Issue Date: 2002
Language: English
Abstract: Repeated blood transfusions in patients with thalassaemia subject them to peroxidative tissue injury by secondary iron overload. To study the relationship between iron overload and antioxidant micronutrient status among children with thalassaemia, we measured serum levels of vitamins A and E, zinc, selenium, and copper in 64 children with beta-thalassaemia major and 63 age- and sex-matched controls. All of these elements were significantly lower in the thalassaemic children compared with controls. There was a highly significant inverse correlation between serum ferritin and serum retinol levels, and significant inverse correlations between serum iron and retinol and between serum iron and selenium. Serum ferritin showed a significant positive correlation with duration of chelation and transfusion treatments. Ways are needed to counteract this oxidative damage and its deleterious effect on the prognosis of thalassaemia
Description: 490-495
Keywords: Antioxidants
Blood Transfusion
Case-Control Studies
Chelating Agents
Child, Preschool
Copper
Ferritins
Iron Overload
Micronutrients
Nutrition Assessment
Nutritional Status
Zinc
Subject: beta-Thalassemia
URI: http://www.who.int/iris/handle/10665/119190
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0804_5/emhj_2002_8_4_5_490_495.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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