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Title: Flow cytometric DNA analysis of oral squamous cell carcinoma in Iraqi patients
Authors: Garib, B.T.
Al Ani, S.
Al Alwan, N.
Tillawi, I.S.
Issue Date: 2002
Language: English
Abstract: We studied the DNA content, DNA index and cell cycle parameters that are reliable markers for assessing the proliferative activity and aggressiveness of malignancies. Cytometric DNA analysis was performed on formalin-fixed paraffin embedded sections from 36 Iraqi patients with oral squamous cell carcinoma. The results showed that 20 of 36 cases [55.5%] were diploid, while 15 cases [41.7%] were aneuploid. Significantly higher S-phase fractions and higher DNA indices characterized aneuploid tumours. Nuclear DNA analysis as part of the evaluation of oral squamous cell carcinoma will influence the selection of appropriate treatment strategies
Description: 393-403
Keywords: Aneuploidy
Case-Control Studies
DNA, Neoplasm
Diploidy
Flow Cytometry
Lymphatic Metastasis
Mouth Neoplasms
Prognosis
S Phase
Subject: Carcinoma, Squamous Cell
URI: http://www.who.int/iris/handle/10665/119178
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0802_3/emhj_2002_8_2_3_393_403.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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