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Title: Performance of IgG avidity in an area endemic for schistosomiasis in Egypt
Authors: Abou Basha, L.M.
Shehab, A.Y.
Abdel Fattah, M.
Bassili, A.
Issue Date: 2002
Language: English
Abstract: We assessed the performance of IgG avidity in the diagnosis of acute, chronic and recent [reinfection] on top of chronic schistosomal infections in patients treated with praziquantel. Immunoglobulin levels were studied in 111 patients with Schistosoma mansoni infection and 28 partially cured patients [not responding to the first dose of praziquantel treatment and almost cured after a second one]. Before treatment all patients with schistosomiasis had elevated IgG levels, 75% of them also had increased IgM levels. Avidity index was high among all age groups. The increased IgM/IgG ratio and avidity index among children with schistosomiasis before treatment support the idea of reinfection. Treatment had no significant effect on the studied parameters. We conclude that unlike IgM and IgG antibody levels, IgG avidity test cannot be used to distinguish between recent and chronic infections
Description: 172-180
Keywords: Antibodies, Protozoan
Antibody Affinity
Chronic Disease
Drug Monitoring
Enzyme-Linked Immunosorbent Assay
Feces
Immunoglobulin G
Immunoglobulin M
Schistosoma mansoni
Severity of Illness Index
Subject: Schistosomiasis mansoni
URI: http://www.who.int/iris/handle/10665/119149
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0801/EMHJ_2002_8_1_172_180.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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