|Title:||Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver|
|Authors:||El Sawy, S.A.|
El Shafey, A.M.
El Bahrawy, H.A.
|Abstract:||This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans|
Cytochrome P-450 Enzyme System
Disease Models, Animal
Liver Function Tests
|Appears in Collections:||EMRO Journal Articles (EMHJ)|
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