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Title: Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver
Authors: El Sawy, S.A.
El Shafey, A.M.
El Bahrawy, H.A.
Issue Date: 2002
Language: English
Abstract: This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans
Description: 95-104
Keywords: Adjuvants, Immunologic
Carbon Tetrachloride
Cytochrome P-450 Enzyme System
Disease Models, Animal
Liver Diseases
Liver Function Tests
Subject: Liver
ISSN: 1020-3397
Other Identifiers:
Appears in Collections:EMRO Journal Articles (EMHJ)

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