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Title: Red cell glucose-6-phosphate dehydrogenase phenotypes in Iraq
Authors: Hilmi, F.A.
Al Allawi, N.A.
Rassam, M.
Al Shamma, G.
Al Hashimi, A.
Issue Date: 2002
Language: English
Abstract: We attempted to characterize biochemically glucose-6-phosphate dehydrogenase [G6PD] variants in Iraqi individuals. Thus 758 healthy Iraqi males aged 18-60 years were randomly selected and 46 [6.1%] were G6PD deficient. Although the predominant non-deficient G6PD phenotype was G6PD B [92.6%], G6PD A+ was found in polymorphic frequency [1.3%]. In the deficient group, 31 cases were fully characterized, including 17 cases with features consistent with G6PD Mediterranean variant, while 12 had other biochemical features and were labelled as non-Mediterranean variant. The remaining two deficient cases were characterized as G6PD A- variant. The presence of a significant number of non-Mediterranean variant was unexpected and may be related to the more heterogeneous background of the Iraqi people
Description: 42-48
Keywords: Case-Control Studies
Electrophoresis, Cellulose Acetate
Epidemiology, Molecular
Gene Frequency
Genetic Heterogenecity
Glucosephosphate Dehydrogenase
Polymorphism, Genetic
Variation [Genetics]
Subject: Glucosephosphate Dehydrogenase Deficiency
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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