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Title: Urinary N-acetyl-beta-D-glucosaminidase in children with diabetes as an early marker of diabetic nephropathy
Authors: Abdel Shakour, S.
El Hefnawy, H.
El Yamani, M.Y.
Azmi, Y.
Issue Date: 2002
Language: English
Abstract: We investigated urinary N-acetyl-beta-D-glucosaminidase [NAG] levels in children with type 1 diabetes as an early marker of tubular damage and studied its correlation with microalbuminuria and glycaemic control. The study group comprised 42 children with type 1 diabetes and 20 healthy children as control. Urinary NAG to urinary creatinine ratio, microalbuminuria, glycated haemoglobin [Hb A1c], blood urea and serum creatinine were estimated. Urinary NAG levels in the children with diabetes were significantly higher than those of controls. There were positive correlations between urinary NAG levels and microalbuminuria, Hb A1c and systolic and diastolic blood pressure values. We found that 59.5% of diabetic children were positive for urinary NAG, while 38.1% of them were positive for microalbuminuria
Description: 24-30
Keywords: Diabetic Nephropathies
Biological Markers
Blood Pressure
Blood Urea Nitrogen
Case-Control Studies
Child, Preschool
Diabetes Mellitus, Type 1
Hemoglobin A, Glycosylated
Subject: Acetylglucosaminidase
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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