Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran
AbstractWe report the results of allogeneic bone marrow transplantation in 26 female and 37 male patients with beta-thalassaemia major [age range: 2-17 years], performed at Namazi Hospital over the period 1992-99. In all cases, standard conditioning and immunosuppressive regimens were employed. Currently, 50 patients remain thalassaemia-free, 9 of whom have developed chronic graft-versus-host disease. There were 8 deaths among the 13 unsuccessful transplant cases: 4 due to acute uncontrollable graft-versus-host disease, and 4 to non-transplant-related causes such as hypoglycaemia, hypersensitivity reactions and advanced disease. We conclude that allogeneic bone marrow transplantation is an effective therapy for the treatment of beta-thalassaemia major, particularly for patients classified as classes I and II
Khojasteh, H.N., Zakerinia, M., Ramzi, M. & Haghshenas, M. (2001). Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran. http://www.who.int/iris/handle/10665/119097
EMHJ - Eastern Mediterranean Health Journal, 7 (4-5), 835-837, 2001
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First Global Consultation on Regulatory Requirements for Human Cells and Tissues for Transplantation, Ottawa, 29 November to 1December 2004 : report Global Consultation on Regulatory Requirements for Human Cells and Tissues for Transplantation (1st : 2004 : Ottawa, Canada); World Health Organization. Dept. of Essential Health Technologies, (2005)