|Title:||Effect of interferon therapy on fatty acid saturation index in hepatitis C virus infection|
|Authors:||Abdel Aziz, M.T.|
Abdel Ghaffar, Y.
Abdel Aziz, D.M.
El Magd, A.A.
|Abstract:||The ratio of stearic to oleic acids, i.e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity|
Drug Therapy, Combination
Hepatitis C, Chronic
Severity of Illness Index
|Appears in Collections:||EMRO Journal Articles (EMHJ)|
Items in WHO IRIS are protected by copyright, with all rights reserved, unless otherwise indicated.