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Title: Effect of interferon therapy on fatty acid saturation index in hepatitis C virus infection
Authors: Abdel Aziz, M.T.
Abdel Ghaffar, Y.
Fouad, H.H.
Abdel Aziz, D.M.
El Magd, A.A.
Issue Date: 2001
Language: English
Abstract: The ratio of stearic to oleic acids, i.e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity
Description: 779-786
Keywords: Antiviral Agents
Biological Markers
Case-Control Studies
Chromatography
Drug Therapy, Combination
Erythrocyte Membrane
Hepatitis C, Chronic
Oleic Acids
Severity of Illness Index
Stearic Acids
Stearoyl-CoA Desaturase
Viral Load
Subject: Interferon-alpha
URI: http://www.who.int/iris/handle/10665/119088
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0704_5/EMHJ_2001_7_4-5_779_786.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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