Effect of interferon therapy on fatty acid saturation index in hepatitis C virus infection
AbstractThe ratio of stearic to oleic acids, i.e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity
Abdel Aziz, M.T., Abdel Ghaffar, Y., Fouad, H.H., Abdel Aziz, D.M. & El Magd, A.A. (2001). Effect of interferon therapy on fatty acid saturation index in hepatitis C virus infection. http://www.who.int/iris/handle/10665/119088
EMHJ - Eastern Mediterranean Health Journal, 7 (4-5), 779-786, 2001
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