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Title: Differential display analysis of mRNAs in chronic myelogenous leukaemia
Authors: El Awady, M.K.
Abdalla, N.M.
Salem, A.M.
Samir, S.
Nour, A.M.
Issue Date: 2001
Language: English
Abstract: Analysis of expressed mRNAs with differential display-polymerase chain reaction [DD-PCR] is a powerful tool for the characterization of genes involved in malignant pathways and might identify markers for different phases of chronic myelogenous leukaemia [CML]. We examined the presence of BCR-ABL transcripts in 25 CML patients in either the chronic phase or blast crisis. We then analysed the expression of leukocytic RNA transcripts in CML phases. DD-PCR technique was used to examine CML cases with BCR-ABL in comparison with CML cases lacking detectable BCR-ABL transcripts. Our results support the use of differential display not only for characterization of the CML differentially expressed genes but also to locate patterns that can be implemented as valuable fingerprints for each phase of CML
Description: 707-715
Keywords: Alternative Splicing
Blast Crisis
Cytogenetic Analysis
Fusion Proteins, bcr-abl
Gene Expression Profiling
Genes, abl
RNA, Messenger
RNA, Neoplasm
Subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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