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Title: New biochemical markers in chronic heart failure
Authors: El Bindary, E.M.
Darwish, A.Z.
Issue Date: 2001
Language: English
Abstract: We investigated the plasma levels of tumour necrosis factor-alpha [TNF-alpha], leptin and insulin, and their relation to body mass index [BMI] in 80 male patients who presented with chronic heart failure [mean age: 47 +/- 4 years] at Tanta University Hospital. Plasma leptin, TNF-alpha and insulin were significantly increased and BMI significantly decreased in New York Heart Association classes III and IV patients. TNF-alpha, leptin and insulin were positively correlated, and TNF-alpha and BMI and leptin and BMI were negatively correlated in stages III and IV of heart failure. We conclude that cytokine neuroendocrine activation may form part of advanced stage heart failure. It may also be responsible for worsening cachexia, and can be used as a marker to determine disease severity
Description: 697-706
Keywords: Body Mass Index
Cachexia
Case-Control Studies
Chronic Disease
Heart Failure
Hyperinsulinism
Immunoenzyme Techniques
Insulin
Leptin
Neurosecretory Systems
Pulmonary Wedge Pressure
Radioimmunoassay
Subject: Biological Markers
URI: http://www.who.int/iris/handle/10665/119077
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0704_5/EMHJ_2001_7_4-5_697_706.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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