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Title: TNF-alpha and homocysteine levels in type 1 diabetes mellitus
Authors: Abdel Aziz, M.T.
Fouad, H.H.
Mohsen, G.A.
Mansour, M.
Abdel Ghaffar, S.
Issue Date: 2001
Language: English
Abstract: The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha [TNF-alpha] as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications
Description: 679-688
Keywords: Albuminuria
Cholesterol, LDL
Diabetic Angiopathies
Diabetic Neuropathies
Hemoglobin A, Glycosylated
Tumor Necrosis Factor-alpha
Subject: Diabetes Mellitus, Type 1
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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