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Title: Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis
Authors: Kheir, M.M.
Issue Date: 2000
Language: English
Abstract: The long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection [400 eggs/g of faeces] from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high [community-wide, up to 11/100 infected patients with bleeding]. Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution
Description: 926-931
Keywords: Praziquantel
Esophageal and Gastric Varices
Schistosomiasis mansoni
Liver Cirrhosis
Schistosomiasis mansoni
Subject: Schistosomiasis mansoni
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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