Files in This Item:
   
Thumbnailemhj_2000_6_4_644_651.pdf

View/Open

Title: Vaccines: World Health Organization versus Federal Drug Administration recommended formula
Authors: Khalil, M.K.
Al Mazrou, Y.Y.
Al Ghamdi, Y.S.
Issue Date: 2000
Language: English
Abstract: Vaccines produced in accordance with WHO formulas, differ in concentration from those used in United States according to FDA formulas. We aimed to compare the immunogenicity of both formulas. Infants who were 6 weeks old were randomly put into 3 groups to receive 3 doses of vaccines at 6 weeks, 3 months and 5 months of age. The vaccines consisted of Haemophilus influenzae type b vaccine, diphtheria-tetanus-pertussis and oral polio vaccine. Antibody levels for polyribosylribitol phosphate [PRP], tetanus, diphtheria and poliovirus were measured 1 month after the third dose of vaccines. Although diphtheria and tetanus antigens in the FDA formula are half the concentration of the WHO formula, anti-tetanus and anti-diphtheria antibodies were significantly higher. No difference was found between groups regarding oral poliovirus vaccine
Description: 644-651
Keywords: Antibodies, Bacterial
Antibodies, Viral
Bordetella pertussis
Clostridium tetani
Diphtheria-Tetanus-Pertussis Vaccine
Haemophilus Vaccines
Haemophilus influenzae
Pharmacopoeias as Topic
Poliovirus
Poliovirus Vaccine, Oral
United States Food and Drug Administration
Subject: World Health Organization
URI: http://www.who.int/iris/handle/10665/118913
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0604/emhj_2000_6_4_644_651.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



Items in WHO IRIS are protected by copyright, with all rights reserved, unless otherwise indicated.