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Title: Assessment of response to tamoxifen among Iraqi patients with advanced breast cancer
Authors: Al Alwan, N.A.S.
Al Kubaisy, W.
Al Rawaq, K.
Issue Date: 2000
Language: English
Abstract: Eighty-eight women presenting with locally advanced or metastatic breast cancer were treated with tamoxifen alone. Estrogen and progesterone receptors [ER and PR] were immunocytochemically analysed in mammary tumour cells obtained by fine needle sampling from 73 patients. Of the breast carcinomas, 34.2% were ER+/PR+ and 43.8% were ER-/PR-. The ER+ content increased with age in postmenopausal women. After tamoxifen treatment objective remission occurred in 39.7% of the women. The overall response rate was 53.3% in the ER+/PR- group and 73.1% in the ER+/PR+ group. However, the response elicited in a case of the ER-/PR- phenotype justified the randomized use of tamoxifen among patients in Iraq where the necessary requirements for hormone receptor assessment are almost unavailable
Description: 475-482
Keywords: Tamoxifen
Neoplasm Metastasis
Neoplasm Invasiveness
Receptors, Estrogen
Subject: Breast Neoplasms
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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