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dc.contributorDiwan, F.H.EN
dc.contributorAbdel Hassan, I.A.EN
dc.contributorMohammed, S.T.EN
dc.date.accessioned2014-06-17T10:48:55Z
dc.date.available2014-06-17T10:48:55Z
dc.date.issued2000EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/0602_3/emhj_2000_6_2_3_345_351.pdfEN
dc.identifier.urihttp://www.who.int/iris/handle/10665/118875
dc.description345-351EN
dc.description.abstractWe evaluated the acute toxicity and histopathological effects of saponin [‎extracted from the plant Citrullus colocynthis]‎ on mice in order to assess its safety. The median lethal dose [‎LD50]‎ of the saponin was 200 mg/kg. The histological changes were confined to the small intestine, liver and kidney, whereas the stomach, large intestine and heart appeared normal. The changes in the small intestine included haemorrhage and erosion of the mucosa. In addition, hepatorenal damage resulted from necrosis of liver cells and renal tubulesEN
dc.language.isoenEN
dc.relation.ispartofseriesEMHJ - Eastern Mediterranean Health Journal, 6 (‎2-3)‎, 345-351, 2000EN
dc.subjectPlants, MedicinalEN
dc.subjectMiceEN
dc.subjectMortalityEN
dc.subjectHistologyEN
dc.subjectPathologyEN
dc.subject.meshSaponinsEN
dc.titleEffect of saponin on mortality and histopathological changes in miceEN


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