Files in This Item:


Title: Molecular studies on Yemeni sickle-cell-disease patients: Xmn I polymorphism
Authors: El Hazmi, M.A.
Warsy, A.S.
Issue Date: 1999
Language: English
Abstract: Our studies of the Saudi population have shown that in patients with mild presentation of sickle-cell disease [SCD] from Saudi Arabia's eastern region, the prevalence of polymorphic sites is high. However, the prevalence is very low in patients with severe SCD from the south-west of the country. We expanded these studies to a group of Yemeni patients with severe SCD, resident in Riyadh. We investigated a total of 60 chromosomes carrying the sickle-cell [Hb S] gene and 14 chromosomes carrying the Hb A gene. Amongst the Hb AA group, the prevalence was 42.9% and 57.1% for the presence [+] and absence [-] of Xmn I polymorphic sites. In the Hb SS individuals, the prevalence of Xmn I polymorphic sites was similar to the prevalence reported in the south-western region of Saudi Arabia
Description: 1183-1187
Keywords: Case-Control Studies
Deoxyribonucleases, Type II Site-Specific
Erythrocyte Count
Erythrocyte Indices
Hemoglobin A
Hemoglobin, Sickle
Polymorphism, Genetic
Severity of Illness Index
Subject: Anemia, Sickle Cell
ISSN: 1020-3397
Other Identifiers:
Appears in Collections:EMRO Journal Articles (EMHJ)

Items in WHO IRIS are protected by copyright, with all rights reserved, unless otherwise indicated.