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Title: Haplotypes of the beta-globin gene as prognostic factors in sickle-cell disease
Authors: El Hazmi, M.A.
Warsy, A.S.
Bashir, N.
Beshlawi, A.
Hussain, I.R.
Temtamy, S.
Qubaili, F.
Issue Date: 1999
Language: English
Abstract: We collaborated with researchers from Egypt, Syrian Arab Republic and Jordan in a study of patients with sickle-cell disease from those countries, and from various parts of Saudi Arabia, in order to investigate the influence of genetics on the clinical presentation of the disease, and to attempt to determine the origin of the sickle-cell gene in Arabs. Our results suggest that beta-globin gene haplotypes influence the clinical presentation of sickle-cell disease, and that there are at least two major foci for the origin of the sickle-cell gene, one in the eastern part of Saudi Arabia, and the other in the populations of North Africa and the north-western part of the Arabian peninsula
Description: 1154-1158
Keywords: Genetic Screening
Polymorphism, Genetic
Residence Characteristics
Severity of Illness Index
Variation [Genetics]
Subject: Anemia, Sickle Cell
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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