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Title: Long-term immunogenicity and efficacy of a recombinant hepatitis B vaccine in Egyptian children
Authors: El Sawy, I.H.
Mohamed, O.N.
Issue Date: 1999
Language: English
Abstract: In 1992, Egypt adopted a hepatitis B vaccine schedule at 2, 4 and 6 months of age. We evaluated the long-term immunogenicity and efficacy of vaccination using this schedule in 180 children whose time lapse since last vaccination varied between 1 month and 5 years. None of the participants had clinical hepatitis, HBsAg was not detected in any participant and all but one had negative results for anti-HBc test. Although a high seroprotection rate [93.3%] was elicited 1 month after vaccination, there were low initial anti-HBs concentrations and both declined rapidly over time. Thus, the short interval [2 months] between the second and third doses of vaccine is less desirable in the long term. We recommend booster inoculations for all previously vaccinated children and a new vaccination schedule at 1, 2 and 9 months
Description: 922-932
Keywords: Child, Preschool
Cross-Sectional Studies
Hepatitis B Antibodies
Hepatitis B Core Antigens
Hepatitis B Surface Antigens
Immunization Schedule
Immunization, Secondary
Time Factors
Vaccines, Synthetic
Subject: Hepatitis B Vaccines
URI: http://www.who.int/iris/handle/10665/118780
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0505/emhj_1999_5_5_922_932.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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