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Title: Immunohistochemical detection of p53 protein in ameloblastoma types
Authors: El Sissy, N.A.
Issue Date: 1999
Language: English
Abstract: Overexpression of p53 protein in unicystic ameloblastoma [uAB] is denser than in the conventional ameloblastoma [cAB] type, indicating increased wild type p53 - suppressing the growth potential of uAB and denoting the early event of neoplastic transformation, probably of a previous odontogenic cyst. Overexpression of p53 in borderline cAB and malignant ameloblastoma [mAB] types might reflect a mutational p53 protein playing an oncogenic role, promoting tumour growth. Overexpression of p53 protein could be a valid screening method for predicting underlying malignant genetic changes in AB types, through increased frequency of immunoreactive cells or increased staining density
Description: 478-489
Keywords: Immunohistochemistry
Mandibular Neoplasms
Maxillary Neoplasms
Subject: Ameloblastoma
URI: http://www.who.int/iris/handle/10665/118731
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0503/EMHJ_1999_5_3_478_489.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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