|Title:||Acute graft-versus-host disease in thalassaemic marrow transplantation with low-dose antithymocyte globulin|
|Abstract:||Our unit performed transplantations on 21 classes II and III thalassaemic patients [class II patients had either hepatomegaly or portal fibrosis and class III patients had both]. We used busulfan [15 mg/kg] and cyclophosphamide [200 mg/kg]. Graft-versus-host disease [GVHD] prophylaxis was cyclosporin, prednisolone and low-dose antithymocyte globulin. Our patient data showed a low incidence of acute GVHD following transplantation. We offer this regimen as an acceptable therapy for thalassaemic patients undergoing allogeneic marrow transplantation as a safe clinical procedure, irrespective of the class of patient|
|Keywords:||Graft Vs Host Disease|
Bone Marrow Transplantation
|Subject:||Graft vs Host Disease|
|Appears in Collections:||EMRO Journal Articles (EMHJ)|
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