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Title: Nucleolus organizer region heteromorphism in patients with Down syndrome and their parents
Authors: Nazmy, N.A.
Kotb, S.M.
Mokhtar, M.M.
Ismail, S.R.
Issue Date: 1999
Language: English
Abstract: The study aimed to evaluate the role of nucleolus organizer region [NOR] heteromorphism as an etiological factor for parental nondisjunction in Down syndrome by comparing 25 patients affected by Down syndrome, and their parents with a control group of 80 non-affected Egyptians. All parents had normal karyotypes. The average modal number per parent of Ag-positive NORs was significantly higher in parents than controls. A significant difference in the size of the double-NOR variants [dNORs] was found. The mean maternal and paternal ages were significantly lower, with a significant increase in spontaneous abortions, for dNOR[+] couples compared with dNOR[-] couples
Description: 299-306
Keywords: Abortion, Spontaneous
Case-Control Studies
Down Syndrome
Infant, Newborn
Karyotyping
Maternal Age
Nondisjunction, Genetic
Pedigree
Pregnancy
Subject: Nucleolus Organizer Region
URI: http://www.who.int/iris/handle/10665/118708
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/0502/EMHJ_1999_5_2_299_306.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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