Study of host immunity in patients with Helicobacter pylori-related idiopathic thrombocytopenia
AbstractTo test the role of T helper cell Th1 immunity we recruited 24 patients with idiopathic thrombocytopenia associated with H. pylori seropositivity. They were divided into 2 groups: 12 with immune-mediated thrombocytopenia [Group 1] and 12 with non-immune mediated thrombocytopenia [Group 2]. We also recruited 10 individuals seronegative for H. pylori [Group 3] as controls. Initial platelet count was significantly lower in Group 1 than Group 2. H. pyloriwas eradicated in 10 of 12 patients in Group 1 and in all patients in Group 2. Transient improvement [< 3 months] in the platelet count occurred in only 2 patients in Group 1 while improvement for > 6 months was observed in all patients in Group 2. There was a statistically significant direct correlation between platelet count and levels of TNF- and IFN-gamma in both study groups, while a non-significant correlation was seen in Group 3. Thus, H. pyloriinfection should be considered in the differential diagnosis of all cases of thrombocytopenia, and should be eradicated in all H. pylori-positive patients with thrombocytopenia
Zahran, S.M., Hamed, N.A., Dafrawy, M., Abdelaziz, H.K. & Morsi, M.G. (2013). Study of host immunity in patients with Helicobacter pylori-related idiopathic thrombocytopenia. http://www.who.int/iris/handle/10665/118570
EMHJ - Eastern Mediterranean Health Journal, 19 (7), 676 - 681, 2013
Description676 - 681
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