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Title: Relation between serum ferritin and liver and heart MRI T2 in beta thalassaemia major patients
Authors: Azarkeivan, A.
Hashemieh, M.
Akhlaghpoor, S.
Shirkavand, A.
Yaseri, M.
Sheibani, K.
Issue Date: 2013
Language: English
Abstract: There is a need for higly accurate non-invasive methods for assessing organ iron content in thalassaemia patients. This study evaluated the relation between serum ferritin level, liver enzyme levels and hepatitis C antibody and liver and heart iron deposition assessed by MRI T2 Data were obtained from the medical records of 156 thalassemia major patients in Tehran. There was a moderate negative correlation between serum ferritin and liver MRI T2 relaxation time [r= -0.535] and a weak negative correlation between serum ferritin and heart MRI T2 relaxation time [r= -0.361]. Hepatitis C infection and liver enzyme levels did not confound or modify the relation between ferritin and liver or heart MRI T2. Liver and heart MRI T2* readings were poorly correlated [r= 0. 281]. Routine evaluation of liver and heart iron content using MRI T2 is suggested to better evaluate the haemosiderosis status in thalassemia patients
Description: 727 - 732
Keywords: Ferritins
Magnetic Resonance Imaging
Hepatitis C Antibodies
Cross-Sectional Studies
Liver Function Tests
Subject: beta-Thalassemia
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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