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Title: Natural killer cell populations in Egyptians infected with hepatitis C virus
Authors: Rafik, M.
Sidhom, G.
Mamdouh, R.
Ellebedy, D.
Mohamed, M.
Keywords: Hepatitis C
Hepacivirus
Hepatitis C Antibodies
Antigens, CD56
Hepatitis C, Chronic
Issue Date: 2012
Relation: EMHJ - Eastern Mediterranean Health Journal, 18 (9), 969 - 973, 2012
Language: English
Abstract: Natural killer [NK] cells are key players in the immune response to viruses. This study examined the effect of hepatitis C virus [HCV] on the frequency of NK cells and their subsets in individuals with different clinical outcomes; 20 positive for anti-HCV and HCV-RNA [chronic hepatitis C], 20 positive for anti-HCV but negative for HCV-RNA [spontaneously resolved] and 20 healthy controls free of HCV. There was a significant reduction in the frequency of total NK cells in the chronic group compared to the control [P= 0.001] or resolved [P= 0.01] groups. The percentage of CD56 [bright] cells was significantly higher than the control group [P= 0.04]. While the percentages of CD56 [dim] cells and their CD16 expression were lower in the chronic group, this was not statistically significant. The frequency of CD3+CD56- T cells was significantly lower in both the chronic and resolved groups compared to the control group [P= 0.04]. Our results confirm a potential role of NK cells and the different subsets in the pathogenesis of chronic HCV infection
Description: 969 - 973
Subject: Killer Cells, Natural
URI: http://www.who.int/iris/handle/10665/118521
ISSN: 1020-3397
Appears in Collections:Journal Articles



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