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|Title: ||Natural killer cell populations in Egyptians infected with hepatitis C virus|
|Authors: ||Rafik, M.|
|Keywords: ||Hepatitis C|
Hepatitis C Antibodies
Hepatitis C, Chronic
|Issue Date: ||2012|
|Relation: ||EMHJ - Eastern Mediterranean Health Journal, 18 (9), 969 - 973, 2012|
|Abstract: ||Natural killer [NK] cells are key players in the immune response to viruses. This study examined the effect of hepatitis C virus [HCV] on the frequency of NK cells and their subsets in individuals with different clinical outcomes; 20 positive for anti-HCV and HCV-RNA [chronic hepatitis C], 20 positive for anti-HCV but negative for HCV-RNA [spontaneously resolved] and 20 healthy controls free of HCV. There was a significant reduction in the frequency of total NK cells in the chronic group compared to the control [P= 0.001] or resolved [P= 0.01] groups. The percentage of CD56 [bright] cells was significantly higher than the control group [P= 0.04]. While the percentages of CD56 [dim] cells and their CD16 expression were lower in the chronic group, this was not statistically significant. The frequency of CD3+CD56- T cells was significantly lower in both the chronic and resolved groups compared to the control group [P= 0.04]. Our results confirm a potential role of NK cells and the different subsets in the pathogenesis of chronic HCV infection|
|Description: ||969 - 973|
|Subject: ||Killer Cells, Natural|
|Appears in Collections:||Journal Articles|
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