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Title: Status of mismatch repair genes hMSH2 and hMSH6 in colorectal cancer in Saudi patients: an immunohistochemical analysis
Authors: Alkhalidi, H.
Kfoury, H.
Issue Date: 2012
Language: English
Abstract: This study aimed to identify the status of 2 major microsatellite instability markers [repair genes hMSH2and hMSH6] in colorectal cancer cases operated at King Khalid University Hospital, Riyadh, Saudi Arabia between 2007 and 2009. Immunohistochemical study of microsatellite instability was done with antibodies to hMSH2and hMSH6. A total of 32 blocks were analysed from patients aged 16-83 years [median 56 years]; 14 blocks [43.8%] were from resections and 18 [56.2%] were from biopsies. An adenomatous component was present in 4 [12.5%] blocks. The colonic carcinoma, the adenomas and the normal tissue showed strong nuclear reactivity to hMSH2and hMSH6in 96.9% of the cases. The rate of loss of expression was 3.1%. The rate of mutation in our sampled population was low and matched the rate reported in the literature from industrialized countries. Further studies are needed to confirm the use of these markers in the diagnosis of colorectal cancer
Description: 1114-1117
Keywords: MutS Homolog 2 Protein
Immunohistochemistry
Microsatellite Instability
DNA Mismatch Repair
DNA-Binding Proteins
Subject: Colorectal Neoplasms
URI: http://www.who.int/iris/handle/10665/118488
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/v18/11/EMHJ_2012_18_11_1102_1106.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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