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Title: Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients
Authors: Hajjaran, H.
Azarian, B.
Mohebali, M.
Hadighi, R.
Assareh, A.
Vaziri, B.
Issue Date: 2012
Language: English
Abstract: In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis [CL], we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor [LACK], alpha tubulin [X2], prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates
Description: 165 - 171
Keywords: Proteomics
Organometallic Compounds
Leishmaniasis, Cutaneous
Electrophoresis, Gel, Two-Dimensional
Mass Spectrometry
Subject: Leishmania tropica
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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