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Title: Interleukins 12 and 13 levels among beta-thalassaemia major patients
Authors: Hashad, R.A.
Hamed, N.A.
El Gharabawy, M.M.
El Metwally, H.A.
Morsi, M.G.
Issue Date: 2013
Language: English
Abstract: The role of inflammatory cytokines in the pathophysiology of beta-thalassaemia is still unclear. In this study production levels of interleukins [IL]-12 and IL-13 were measured by commercial ELISA in cultureI supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. IL-12 levels were significantly lower among cases compared with controls [91.4 pg/mL versus 154.6 pg/mL] while IL-13 levels were significantly higher [42.5 pg/mLversus 5.7 pg/mL]. There was a significant negative correlation between IL-12 and IL-13 levels among beta-thalassaemia cases [r= -0.42]. Patients with beta-thalassaemia alone had higher IL-12 levels than beta-thalassaemia patients who were seropositive for chronic hepatitis B or C virus Infection [140 pg/mL versus 50 pg/mL]; IL-13 levels were slightly lower [65 pg/mL versus 67 pg/mL]. An imbalance In the IL-12/IL-13 axis may be relevant to the pathophysiology of beta-thalassaemia
Description: 181-185
Keywords: Interleukin-12
Interleukin-13
Enzyme-Linked Immunosorbent Assay
Hepatitis B, Chronic
Hepatitis C, Chronic
Case-Control Studies
Subject: beta-Thalassemia
URI: http://www.who.int/iris/handle/10665/118433
ISSN: 1020-3397
Other Identifiers: http://applications.emro.who.int/emhj/v19/02/EMHJ_2013_19_2_181_185.pdf
Appears in Collections:EMRO Journal Articles (EMHJ)



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