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Title: Hepatitis B surface antigen carrier rate in unvaccinated and vaccinated children with thalassaemia major at Bahawal Victoria Hospital, Bahawalpur, Pakistan
Authors: Rehman, A.
Mazhar, A.
Sheikh, M.A.
Naeem, M.M.
Bhatti, A.
Issue Date: 2012
Language: English
Abstract: Screening of blood reduces but does not eliminate the risk of hepatitis B virus [HBV] infection in multi-transfused thalassaemia patients. This study was done to evaluate efficacy of HBV vaccination on hepatitis B virus surface antigen [HBsAg] carrier rate in children with thalassaemia major receiving multiple blood transfusions. In a cohort study conducted at a hospital in Bahawalpur, Pakistan, during 2009-10, children with thalassaemia major aged < 60 months who received more than 24 blood transfusions and were HBsAg negative at the time of first blood transfusion were included. Of 196 unvaccinated children, the seropositive rate was 12.2%; while among 218 children vaccinated during the first year of life via the Pakistan Expanded Programme on Immunization, the seropositive rate was only 0,9%. The HBV vaccine was highly effective in reducing the HBsAg carrier rate in children with thalassaemia aged < 5 years
Description: 378-381
Keywords: Hepatitis B Surface Antigens
Hepatitis B Vaccines
Carrier State
Cohort Studies
Subject: Hepatitis B
ISSN: 1020-3397
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Appears in Collections:EMRO Journal Articles (EMHJ)

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